BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PHGDH
3-PGDH, 3PGDH, 4930479N23, A10, PGAD, PGD, PGDH, SERA
3-phosphoglycerate dehydrogenase
GO Process (14)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- G1 to G0 transition [IMP]
- L-serine metabolic process [IMP]
- gamma-aminobutyric acid metabolic process [IMP]
- glial cell development [IMP]
- glutamine metabolic process [IMP]
- glycine metabolic process [IMP]
- neural tube development [IMP]
- neurogenesis [IMP]
- neuron projection development [IMP]
- oxidation-reduction process [ISO]
- regulation of gene expression [IMP]
- spinal cord development [IMP]
- taurine metabolic process [IMP]
- threonine metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondria-ER appositions are destroyed during mitophagy, and reducing mitochondria-ER contacts increases the rate of mitochondrial degradation. Mechanistically, parkin/PINK1 catalyze a ... [more]
Elife Apr. 20, 2018; 7(); [Pubmed: 29676259]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- likely protein-protein interaction
Curated By
- BioGRID