BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RBCK1
AL033326, HOIL-1, HOIL-1L, UIP28, Ubce7ip3, RP23-452D3.5
RanBP-type and C3HC4-type zinc finger containing 1
GO Process (12)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- T cell receptor signaling pathway [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of necroptotic process [IGI]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- positive regulation of NF-kappaB import into nucleus [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein linear polyubiquitination [ISO]
- protein polyubiquitination [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondria-ER appositions are destroyed during mitophagy, and reducing mitochondria-ER contacts increases the rate of mitochondrial degradation. Mechanistically, parkin/PINK1 catalyze a ... [more]
Elife Apr. 20, 2018; 7(); [Pubmed: 29676259]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- likely protein-protein interaction
Related interactions
Curated By
- BioGRID