BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MAP3K7
B430101B05, C87327, Tak1, RP23-447J12.1
mitogen-activated protein kinase kinase kinase 7
GO Process (14)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- I-kappaB phosphorylation [IGI]
- MAPK cascade [IDA]
- activation of MAPK activity [IDA]
- angiogenesis [IMP]
- negative regulation of apoptotic signaling pathway [IGI, IMP]
- negative regulation of necroptotic process [IMP]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of ripoptosome assembly involved in necroptotic process [IGI]
- neural tube formation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI]
- positive regulation of JNK cascade [IGI]
- protein phosphorylation [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondria-ER appositions are destroyed during mitophagy, and reducing mitochondria-ER contacts increases the rate of mitochondrial degradation. Mechanistically, parkin/PINK1 catalyze a ... [more]
Elife Apr. 20, 2018; 7(); [Pubmed: 29676259]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- likely protein-protein interaction
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
UBC MAP3K7 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | High | - | BioGRID | 2297225 |
Curated By
- BioGRID