BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BRCC3
C6.1A, RP23-252K7.4
BRCA1/BRCA2-containing complex, subunit 3
GO Process (9)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- G2 DNA damage checkpoint [ISO]
- double-strand break repair [ISO]
- histone H2A K63-linked deubiquitination [ISO]
- positive regulation of DNA repair [ISO]
- protein K63-linked deubiquitination [ISO]
- proteolysis [ISO]
- regulation of catalytic activity [ISO]
- response to X-ray [ISO]
- response to ionizing radiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondria-ER appositions are destroyed during mitophagy, and reducing mitochondria-ER contacts increases the rate of mitochondrial degradation. Mechanistically, parkin/PINK1 catalyze a ... [more]
Elife Apr. 20, 2018; 7(); [Pubmed: 29676259]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- likely protein-protein interaction
Related interactions
Curated By
- BioGRID