UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MYH9
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- actin cytoskeleton reorganization [ISO]
- actin filament-based movement [ISO]
- actomyosin structure organization [ISO]
- angiogenesis [ISO]
- blood vessel endothelial cell migration [ISO]
- cell adhesion [IMP]
- cell morphogenesis involved in differentiation [IMP]
- cellular component movement [IMP]
- cytokinesis [ISO]
- establishment of T cell polarity [IMP]
- establishment of meiotic spindle localization [IDA]
- in utero embryonic development [IMP]
- meiotic spindle organization [IDA]
- membrane protein ectodomain proteolysis [ISO]
- myoblast fusion [IMP]
- platelet aggregation [ISO]
- platelet formation [ISO]
- protein transport [ISO]
- regulation of cell shape [IMP, ISO]
- single organismal cell-cell adhesion [IMP]
- uropod organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- actin cytoskeleton [ISO]
- actomyosin [ISO]
- actomyosin contractile ring [ISO]
- cell cortex [IDA]
- cell leading edge [ISO]
- cell-cell adherens junction [IDA]
- cleavage furrow [ISO]
- cortical cytoskeleton [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA, ISO]
- integrin complex [ISO]
- membrane [ISO]
- myosin II complex [IDA, ISO]
- myosin II filament [ISO]
- myosin complex [IDA]
- neuromuscular junction [IDA]
- nucleus [ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- ruffle [ISO]
- spindle [IDA]
- stress fiber [IDA, ISO]
- uropod [IDA, ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondria-ER appositions are destroyed during mitophagy, and reducing mitochondria-ER contacts increases the rate of mitochondrial degradation. Mechanistically, parkin/PINK1 catalyze a ... [more]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- likely protein-protein interaction
Curated By
- BioGRID