BAIT
UBE3A
ANCR, AS, E6-AP, EPVE6AP, HPVE6A
ubiquitin protein ligase E3A
GO Process (9)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- androgen receptor signaling pathway [IBA]
- brain development [TAS]
- protein K48-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- proteolysis [TAS]
- regulation of circadian rhythm [IMP]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
KRT6B
CK-6B, CK6B, K6B, KRTL1, PC2, PC4
keratin 6B
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes.
Perturbations in activity and dosage of the UBE3A ubiquitin-ligase have been linked to Angelman syndrome and autism spectrum disorders. UBE3A was initially identified as the cellular protein hijacked by the human papillomavirus E6 protein to mediate the ubiquitylation of p53, a function critical to the oncogenic potential of these viruses. Although a number of substrates have been identified, the normal ... [more]
J. Mol. Biol. Mar. 30, 2018; 430(7);1024-1050 [Pubmed: 29426014]
Throughput
- High Throughput
Ontology Terms
- phenotype: sh-sy5y cell (BTO:0000793)
Additional Notes
- High-confidence candidate-interacting proteins (HCIPs) for wild type UBE3A/E6AP had NWD scores equal to or higher than 1 (CompPASS method).
- UBE3A/E6AP interactor in SH-SY5Y cells detected as HCIP in more than one immunoprecipitation.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBE3A KRT6B | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | High | - | BioGRID | - |
Curated By
- BioGRID