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BAIT

KHSRP

FBP2, FUBP2, KSRP

KH-type splicing regulatory protein

GO Process (5)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

RNA metabolic process [TAS]

RNA splicing [TAS]

RNA splicing, via transesterification reactions [TAS]

gene expression [TAS]

mRNA metabolic process [TAS]

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]

Gene Ontology Cellular Component

nucleoplasm [IDA, TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

EXOSC2

RRP4, Rrp4p, hRrp4p, p7, RP11-57C19.4

exosome component 2

GO Process (15)

GO Function (4)

GO Component (6)

Gene Ontology Biological Process

CUT catabolic process [IBA]

RNA metabolic process [TAS]

U4 snRNA 3'-end processing [IBA]

exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [IBA, TAS]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IBA]

gene expression [TAS]

mRNA metabolic process [TAS]

nuclear polyadenylation-dependent rRNA catabolic process [IBA]

nuclear polyadenylation-dependent tRNA catabolic process [IBA]

nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription [IBA]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]

nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [IBA]

polyadenylation-dependent snoRNA 3'-end processing [IBA]

positive regulation of cell growth [IMP]

rRNA processing [TAS]

Gene Ontology Molecular Function

3'-5'-exoribonuclease activity [TAS]
7S RNA binding [TAS]
exoribonuclease activity [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

cytoplasmic exosome (RNase complex) [IBA]

exosome (RNase complex) [IDA]

nuclear exosome (RNase complex) [IBA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.

Gherzi R, Lee KY, Briata P, Wegmueller D, Moroni C, Karin M, Chen CY

Inherently unstable mRNAs contain AU-rich elements (AREs) in their 3' untranslated regions that act as mRNA stability determinants by interacting with ARE binding proteins (ARE-BPs). The mechanisms underlying the function of ARE and ARE-BP interactions in promoting mRNA decay are not fully understood. Here, we demonstrate that KSRP, a KH domain-containing ARE-BP, is an essential factor for ARE-directed mRNA decay. ... [more]

Mol. Cell Jun. 04, 2004; 14(5);571-83 [Pubmed: 15175153]

Throughput

Low Throughput

Curated By

BioGRID