BAIT
UBE3A
ANCR, AS, E6-AP, EPVE6AP, HPVE6A
ubiquitin protein ligase E3A
GO Process (9)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- androgen receptor signaling pathway [IBA]
- brain development [TAS]
- protein K48-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- proteolysis [TAS]
- regulation of circadian rhythm [IMP]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PAX6
AN, AN2, D11S812E, FVH1, MGDA, WAGR
paired box 6
GO Process (17)
GO Function (10)
GO Component (4)
Gene Ontology Biological Process
- blood vessel development [IMP]
- central nervous system development [TAS]
- cornea development in camera-type eye [IMP]
- eye development [TAS]
- glucose homeostasis [IMP]
- iris morphogenesis [IMP]
- negative regulation of neurogenesis [ISS]
- neuron fate commitment [NAS]
- organ morphogenesis [TAS]
- pancreatic A cell development [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- protein ubiquitination [ISS]
- response to wounding [IEP]
- transcription from RNA polymerase II promoter [IMP]
- visual perception [TAS]
Gene Ontology Molecular Function- DNA binding [TAS]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- histone acetyltransferase binding [ISS]
- protein binding [IPI]
- protein kinase binding [ISS]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [ISS]
- ubiquitin-protein transferase activity [ISS]
- DNA binding [TAS]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- histone acetyltransferase binding [ISS]
- protein binding [IPI]
- protein kinase binding [ISS]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [ISS]
- ubiquitin-protein transferase activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes.
Perturbations in activity and dosage of the UBE3A ubiquitin-ligase have been linked to Angelman syndrome and autism spectrum disorders. UBE3A was initially identified as the cellular protein hijacked by the human papillomavirus E6 protein to mediate the ubiquitylation of p53, a function critical to the oncogenic potential of these viruses. Although a number of substrates have been identified, the normal ... [more]
J. Mol. Biol. Mar. 30, 2018; 430(7);1024-1050 [Pubmed: 29426014]
Throughput
- High Throughput
Curated By
- BioGRID