BAIT
WOR1
TOS9, CA1512, CAWG_00418, IPF15255.2, CaO19.12348, orf6.3050, IPF15255, orf19.12348, YEL007W, CaO6.3050, C1_10150W_B, CaO19.4884, IPF22376.1, orf19.4884, EAP2, C1_10150W, Contig4-2464_0001, C1_10150W_A
Transcription factor ("master switch") of white-opaque phenotypic switching; required to establish and maintain the opaque state; opaque-specific, nuclear; regulates its own expression; suggested role in regulation of adhesion factors
GO Process (0)
GO Function (0)
GO Component (0)
Candida albicans (SC5314)
PREY
RPS21
CaO19.10845, IPF14407.1, C1_01480C, orf19.3334, orf19.10845, CaO6.3341, CA1715, CAWG_01230, CaO19.3334, Contig4-2144_0006, RPS2, IPF23952.1, orf6.3341, C1_01480C_B, C1_01480C_A
Protein component of the small (40S) subunit; repressed upon phagocytosis by murine macrophage; positively regulated by Tbf1; Spider biofilm repressed
GO Process (0)
GO Function (0)
GO Component (0)
Candida albicans (SC5314)
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicans.
The pathogenic fungus Candida albicans can undergo phenotypic switching between two heritable states: white and opaque. This phenotypic plasticity facilitates its colonization in distinct host niches. The master regulator WOR1 is exclusively expressed in opaque phase cells. Positive feedback regulation by Wor1 on the WOR1 promoter is essential for opaque formation, however the underlying mechanism of how Wor1 functions is ... [more]
PLoS Genet. Dec. 01, 2017; 14(1);e1007176 [Pubmed: 29337983]
Throughput
- High Throughput
Curated By
- BioGRID