UTF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
MYC
Gene Ontology Biological Process
- B cell apoptotic process [IMP]
- DNA-templated transcription, initiation [ISO]
- MAPK cascade [ISO]
- Wnt signaling pathway [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- amino acid transport [ISO]
- branching involved in ureteric bud morphogenesis [IMP]
- canonical Wnt signaling pathway [ISO]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IGI]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [IGI]
- canonical Wnt signaling pathway involved in positive regulation of wound healing [ISO]
- cell cycle arrest [ISO]
- cell proliferation [ISO]
- cellular iron ion homeostasis [ISO]
- cellular response to DNA damage stimulus [IDA, ISO]
- cellular response to drug [IDA, ISO]
- chromatin remodeling [ISO]
- chromosome organization [ISO]
- detection of mechanical stimulus involved in sensory perception of sound [IMP]
- glucose metabolic process [ISO]
- inner mitochondrial membrane organization [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA, IMP]
- lactic acid secretion [ISO]
- middle ear morphogenesis [IMP]
- negative regulation of cell death [ISO]
- negative regulation of cell division [ISO]
- negative regulation of fibroblast proliferation [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of glucose import [ISO]
- negative regulation of monocyte differentiation [ISO]
- negative regulation of protein binding [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- pigmentation [IMP]
- positive regulation of ATP biosynthetic process [ISO]
- positive regulation of B cell apoptotic process [IGI]
- positive regulation of DNA biosynthetic process [ISO]
- positive regulation of apoptotic signaling pathway [IDA, IMP]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell cycle [ISO]
- positive regulation of cell proliferation [IDA, IGI, ISO]
- positive regulation of cellular respiration [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of glycolytic process [ISO]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of metanephric cap mesenchymal cell proliferation [IMP]
- positive regulation of mitochondrial membrane potential [ISO]
- positive regulation of response to DNA damage stimulus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein processing [IMP]
- pyruvate transport [ISO]
- regulation of apoptotic process [IDA, IMP]
- regulation of gene expression [IDA, ISO]
- regulation of mitotic cell cycle [ISO]
- regulation of oxidative phosphorylation [ISO]
- regulation of telomere maintenance [ISO]
- regulation of transcription, DNA-templated [IGI, ISO]
- response to alkaloid [IMP]
- response to gamma radiation [ISO]
- response to radiation [IDA, IMP]
- skeletal muscle cell differentiation [IMP]
- skeletal system morphogenesis [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transcription, DNA-templated [ISO]
- transformation of host cell by virus [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- E-box binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- core promoter proximal region sequence-specific DNA binding [IDA]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [ISO]
- DNA binding [IDA, ISO]
- E-box binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- core promoter proximal region sequence-specific DNA binding [IDA]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain.
In order to elucidate the function of Myc in the maintenance of pluripotency and self-renewal in mouse embryonic stem cells (mESCs), we screened for novel ESC-specific interactors of Myc by mass spectrometry. Undifferentiated embryonic cell transcription factor 1 (Utf1) was identified in the screen as a putative Myc binding protein in mESCs. We found that Myc and Utf1 directly interact. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MYC UTF1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID