CRBN
Gene Ontology Biological Process
Gene Ontology Molecular Function
SALL1
Gene Ontology Biological Process
- adrenal gland development [IEP]
- branching involved in ureteric bud morphogenesis [ISS]
- embryonic digestive tract development [IMP]
- embryonic digit morphogenesis [IMP]
- gonad development [IEP]
- heart development [IMP]
- histone deacetylation [ISS]
- inductive cell-cell signaling [ISS]
- kidney development [IMP]
- kidney epithelium development [ISS]
- limb development [IMP]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IEP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- olfactory bulb interneuron differentiation [ISS]
- olfactory bulb mitral cell layer development [IMP]
- olfactory nerve development [ISS]
- outer ear morphogenesis [IMP]
- pituitary gland development [IEP]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- ureteric bud development [ISS]
- ureteric bud invasion [ISS]
- ventricular septum development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
The small molecules thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) by recruiting a Cys2-His2 (C2H2) zinc finger domain to Cereblon (CRBN), the substrate receptor of the CRL4CRBN E3 ubiquitin ligase. We screened the human C2H2 zinc finger proteome for degradation in the presence of thalidomide analogs, identifying 11 ... [more]
Throughput
- Low Throughput
Additional Notes
- With Pomalidomide (CHEBI:72690)
- Zing finger (ZF) bound to CRBN-Pomalidomide in vitro
Curated By
- BioGRID