BAIT
HIF1A
MOP1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
GO Process (107)
GO Function (19)
GO Component (8)
Gene Ontology Biological Process
- B-1 B cell homeostasis [ISO]
- angiogenesis [ISO]
- axon transport of mitochondrion [ISO, ISS]
- blood vessel development [ISO]
- blood vessel morphogenesis [ISO]
- cardiac ventricle morphogenesis [ISO]
- cartilage development [ISO]
- cell differentiation [ISO]
- cellular iron ion homeostasis [ISO]
- cellular response to carbon monoxide [IEP]
- cellular response to cobalt ion [IEP]
- cellular response to drug [IEP]
- cellular response to electrical stimulus [IEP]
- cellular response to glucose stimulus [IEP]
- cellular response to hydrogen peroxide [IEP]
- cellular response to hypoxia [IEP, IMP, ISO, ISS]
- cellular response to insulin stimulus [IEP]
- cellular response to interleukin-1 [IEP, ISO]
- cellular response to light stimulus [IEP]
- cellular response to lipid [IEP]
- cellular response to lipopolysaccharide [IEP]
- cellular response to mechanical stimulus [IEP]
- cellular response to nitrite [IEP]
- cellular response to organic cyclic compound [IEP]
- cellular response to toxic substance [IEP]
- cerebral cortex development [ISO]
- collagen metabolic process [ISO]
- connective tissue replacement involved in inflammatory response wound healing [ISO]
- digestive tract morphogenesis [ISO]
- dopaminergic neuron differentiation [ISO]
- elastin metabolic process [ISO]
- embryonic hemopoiesis [ISO]
- embryonic placenta development [ISO]
- epithelial cell differentiation involved in mammary gland alveolus development [ISO]
- epithelial to mesenchymal transition [ISO]
- glucose homeostasis [ISO]
- heart looping [ISO]
- hemoglobin biosynthetic process [ISO]
- hypoxia-inducible factor-1alpha signaling pathway [ISO]
- intestinal epithelial cell maturation [ISO]
- lactate metabolic process [ISO]
- lactation [ISO]
- maternal process involved in female pregnancy [IEP]
- muscle cell cellular homeostasis [ISO]
- negative regulation of TOR signaling [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of bone mineralization [ISO]
- negative regulation of growth [ISO]
- negative regulation of mesenchymal cell apoptotic process [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- negative regulation of thymocyte apoptotic process [ISO]
- negative regulation of transcription elongation from RNA polymerase II promoter [IMP]
- negative regulation of vasoconstriction [IMP]
- neural crest cell migration [ISO]
- neural fold elevation formation [ISO]
- outflow tract morphogenesis [ISO]
- oxygen homeostasis [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell size [IEP]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of erythrocyte differentiation [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- positive regulation of neuroblast proliferation [ISO]
- positive regulation of receptor biosynthetic process [ISO]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation vascular endothelial growth factor production [ISO, ISS]
- regulation of catalytic activity [ISO]
- regulation of cell proliferation [ISO]
- regulation of cellular response to hypoxia [IEP]
- regulation of gene expression [ISO]
- regulation of glycolytic process [ISO]
- regulation of thymocyte apoptotic process [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP, ISO]
- regulation of transcription, DNA-templated [ISO, TAS]
- regulation of transforming growth factor beta2 production [ISO]
- response to X-ray [IEP]
- response to activity [IEP]
- response to alkaloid [IEP]
- response to anesthetic [IEP]
- response to auditory stimulus [IEP]
- response to cobalt ion [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to estrogen [IEP]
- response to fungicide [IMP]
- response to glucocorticoid [IEP]
- response to glucose [IEP]
- response to hypoxia [IDA, ISO, ISS]
- response to mechanical stimulus [IEP]
- response to muscle activity [ISO]
- response to purine-containing compound [IEP]
- response to salt stress [IEP]
- retina vasculature development in camera-type eye [ISO]
- signal transduction [ISO]
- transcription from RNA polymerase II promoter [ISO]
- vascular endothelial growth factor production [ISO]
- vasculature development [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [ISO]
- double-stranded DNA binding [TAS]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO, ISS]
- histone deacetylase binding [ISO]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [IMP, IPI]
- protein heterodimerization activity [IDA, ISO, ISS]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO, ISS]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- DNA binding [ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [ISO]
- double-stranded DNA binding [TAS]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO, ISS]
- histone deacetylase binding [ISO]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [IMP, IPI]
- protein heterodimerization activity [IDA, ISO, ISS]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO, ISS]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
Rattus norvegicus
PREY
VEGFA
VEGF-A, VEGF164, VPF, Vegf
vascular endothelial growth factor A
GO Process (132)
GO Function (16)
GO Component (7)
Gene Ontology Biological Process
- T-helper 1 type immune response [IDA]
- VEGF-activated neuropilin signaling pathway [ISO]
- activation of protein kinase activity [ISO]
- aging [IEP]
- angiogenesis [IMP, ISO, TAS]
- angiogenesis involved in coronary vascular morphogenesis [IMP]
- artery morphogenesis [ISO]
- basophil chemotaxis [ISO]
- blood vessel development [ISO]
- blood vessel morphogenesis [ISO]
- blood vessel remodeling [IMP]
- branching morphogenesis of an epithelial tube [ISO]
- camera-type eye morphogenesis [ISO]
- cardiac muscle fiber development [ISO]
- cardiac vascular smooth muscle cell development [ISO]
- cell chemotaxis [IMP]
- cell maturation [ISO]
- cell migration [ISO]
- cell migration involved in sprouting angiogenesis [ISO]
- cell proliferation [ISO]
- cellular response to dexamethasone stimulus [IEP]
- cellular response to drug [IEP]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to hypoxia [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- commissural neuron axon guidance [ISO]
- coronary artery morphogenesis [ISO]
- coronary vein morphogenesis [ISO]
- dopaminergic neuron differentiation [ISO]
- endothelial cell chemotaxis [ISO]
- endothelial cell migration [ISO]
- epithelial cell differentiation [ISO]
- eye photoreceptor cell development [ISO]
- female pregnancy [IEP]
- growth [ISO]
- heart morphogenesis [ISO]
- hyaluronan metabolic process [IEP]
- in utero embryonic development [ISO]
- induction of positive chemotaxis [ISO]
- kidney development [ISO]
- lactation [ISO]
- lung alveolus development [IMP]
- lung development [ISO]
- lung vasculature development [ISO]
- lymph vessel morphogenesis [ISO]
- mRNA stabilization [IDA]
- macrophage differentiation [ISO]
- mammary gland alveolus development [ISO]
- mesoderm development [ISO]
- monocyte differentiation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of bone resorption [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of neuron death [IMP]
- negative regulation of programmed cell death [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- nervous system development [IDA, NAS]
- neuron development [ISO]
- outflow tract morphogenesis [ISO]
- ovarian follicle development [ISO]
- patterning of blood vessels [ISO]
- positive chemotaxis [IMP, ISO]
- positive regulation of CREB transcription factor activity [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of angiogenesis [IDA, ISO, ISS]
- positive regulation of axon extension involved in axon guidance [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell migration involved in sprouting angiogenesis [ISO]
- positive regulation of cell proliferation [IMP, ISO, TAS]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [ISO]
- positive regulation of cellular component movement [ISO]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation of endothelial cell migration [ISO, ISS]
- positive regulation of endothelial cell proliferation [ISO, ISS]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of focal adhesion assembly [ISO, ISS]
- positive regulation of gene expression [ISO]
- positive regulation of histone deacetylase activity [ISO]
- positive regulation of lymphangiogenesis [ISO]
- positive regulation of mast cell chemotaxis [ISO]
- positive regulation of mesenchymal cell proliferation [ISO]
- positive regulation of neuroblast proliferation [ISO]
- positive regulation of p38MAPK cascade [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine autophosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO, ISS]
- positive regulation of positive chemotaxis [ISO]
- positive regulation of protein autophosphorylation [ISO]
- positive regulation of protein complex assembly [ISO, ISS]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein kinase C signaling [ISO]
- positive regulation of protein kinase D signaling [ISO]
- positive regulation of protein localization to early endosome [ISO]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of receptor internalization [ISO]
- positive regulation of retinal ganglion cell axon guidance [ISO]
- positive regulation of signal transduction [IDA]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation of vascular permeability [IMP, ISO]
- post-embryonic camera-type eye development [ISO]
- primitive erythrocyte differentiation [ISO]
- regulation of cGMP metabolic process [ISO]
- regulation of cell shape [ISO]
- regulation of endothelial cell differentiation [ISO]
- regulation of hematopoietic progenitor cell differentiation [ISO]
- regulation of retinal ganglion cell axon guidance [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- response to cold [IEP]
- response to dexamethasone [IEP]
- response to estradiol [IEP]
- response to folic acid [IEP]
- response to hypoxia [IDA, ISO]
- response to oxygen levels [IEP]
- response to progesterone [IEP]
- response to vitamin A [IEP]
- sprouting angiogenesis [ISO]
- surfactant homeostasis [ISO]
- tube formation [ISO, ISS]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
- vascular endothelial growth factor signaling pathway [ISO]
- vasculature development [ISO]
- wound healing [IEP]
Gene Ontology Molecular Function- chemoattractant activity [IMP, ISO]
- cytokine activity [ISO]
- extracellular matrix binding [ISO]
- fibronectin binding [ISO]
- growth factor activity [IDA, ISO]
- heparin binding [ISO]
- identical protein binding [ISO]
- neuropilin binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [IDA]
- receptor agonist activity [ISO]
- receptor binding [ISO]
- vascular endothelial growth factor receptor 1 binding [ISO]
- vascular endothelial growth factor receptor 2 binding [IMP, ISO]
- vascular endothelial growth factor receptor binding [ISO, TAS]
- chemoattractant activity [IMP, ISO]
- cytokine activity [ISO]
- extracellular matrix binding [ISO]
- fibronectin binding [ISO]
- growth factor activity [IDA, ISO]
- heparin binding [ISO]
- identical protein binding [ISO]
- neuropilin binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [IDA]
- receptor agonist activity [ISO]
- receptor binding [ISO]
- vascular endothelial growth factor receptor 1 binding [ISO]
- vascular endothelial growth factor receptor 2 binding [IMP, ISO]
- vascular endothelial growth factor receptor binding [ISO, TAS]
Gene Ontology Cellular Component
Rattus norvegicus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis.
The role of prolyl hydroxylase (PHD)-3 as a hypoxia inducible factor (HIF)-1α cofactor is controversial and remains unknown in skeletal tissues. We investigated whether PHD3 controls HIF-1 transcriptional activity in nucleus pulposus (NP) cells through the pyruvate kinase muscle (PKM)-2-Jumonji domain--containing protein (JMJD5) axis. PHD3-/- mice (12.5 mo old) showed increased incidence of intervertebral disc degeneration with a concomitant decrease ... [more]
FASEB J. Dec. 01, 2016; 31(9);3831-3847 [Pubmed: 28495754]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID