CAY1
Gene Ontology Biological Process
Gene Ontology Cellular Component
RAP1
Gene Ontology Biological Process
- chromatin silencing at telomere [IMP]
- meiotic telomere clustering [IMP]
- negative regulation of telomere maintenance via telomerase [IGI]
- negative regulation of telomeric RNA transcription from RNA pol II promoter [IMP]
- protection from non-homologous end joining at telomere [IGI, IMP]
- regulation of transcription from RNA polymerase II promoter [ISS]
- telomere maintenance [IGI]
- telomeric 3' overhang formation [IGI]
- transcription from RNA polymerase II promoter [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels.
The telomeric transcriptome comprises multiple long non-coding RNAs generated by transcription of linear chromosome ends. In a screening performed in Schizosaccharomyces pombe, we identified factors modulating the cellular levels of the telomeric transcriptome. Among these factors, Cay1 is the fission yeast member of the conserved family of Cactins, uncharacterized proteins crucial for cell growth and survival. In cay1∆ mutants, the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CAY1 RAP1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | PomBase | - | |
| RAP1 CAY1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.8601 | BioGRID | 524775 | |
| CAY1 RAP1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | PomBase | - |