DSK1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LKH1
Gene Ontology Biological Process
- cellular response to oxidative stress [IMP]
- intracellular signal transduction [TAS]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IMP]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of barrier septum assembly [IMP]
- regulation of fungal-type cell wall organization [IMP]
- regulation of mitotic cytokinetic cell separation [IMP]
Gene Ontology Molecular Function
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Biochemical and genetic conservation of fission yeast Dsk1 and human SR protein-specific kinase 1.
Arginine/serine-rich (RS) domain-containing proteins and their phosphorylation by specific protein kinases constitute control circuits to regulate pre-mRNA splicing and coordinate splicing with transcription in mammalian cells. We present here the finding that similar SR networks exist in Schizosaccharomyces pombe. We previously showed that Dsk1 protein, originally described as a mitotic regulator, displays high activity in phosphorylating S. pombe Prp2 protein ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DSK1 LKH1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | PomBase | - | |
| LKH1 DSK1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 799896 | |
| LKH1 DSK1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | PomBase | 882972 | |
| LKH1 DSK1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 247662 | |
| DSK1 LKH1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 664521 |