A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Mutational effect of fission yeast polalpha on cell cycle events.

Bhaumik D, Wang TS

Polalpha is the principal DNA polymerase for initiation of DNA replication and also functions in postinitiation DNA synthesis. In this study, we investigated the cell cycle responses induced by mutations in polalpha+. Germinating spores carrying either a deletion of polalpha+ (polalphaDelta) or a structurally intact but catalytically dead polalpha mutation proceed to inappropriate mitosis with no DNA synthesis. This suggests ... [more]

Mol. Biol. Cell Aug. 01, 1998; 9(8);2107-23 [Pubmed: 9693370]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
POL1 RAD26	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Kai M (2003)	Low	-	BioGRID	927708
RAD26 POL1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Liu VF (1999)	Low	-	BioGRID	196578

Curated By

PomBase

Interaction Summary

POL1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA replication origin binding [IDA]DNA-directed DNA polymerase activity [IDA, IGI]chromatin binding [IDA]protein binding [IPI]single-stranded DNA binding [IDA]

Gene Ontology Cellular Component

RAD26