TSEN15
CLP1
Gene Ontology Biological Process
- RNA splicing [TAS]
- cerebellar cortex development [IMP]
- gene expression [TAS]
- mRNA 3'-end processing [TAS]
- mRNA cleavage [IBA]
- mRNA polyadenylation [IBA]
- mRNA splicing, via spliceosome [TAS]
- siRNA loading onto RISC involved in RNA interference [IDA]
- tRNA splicing, via endonucleolytic cleavage and ligation [IDA, IMP]
- targeting of mRNA for destruction involved in RNA interference [IMP]
- termination of RNA polymerase II transcription [TAS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation.
tRNA splicing is a fundamental process required for cell growth and division. The first step in tRNA splicing is the removal of introns catalyzed in yeast by the tRNA splicing endonuclease. The enzyme responsible for intron removal in mammalian cells is unknown. We present the identification and characterization of the human tRNA splicing endonuclease. This enzyme consists of HsSen2, HsSen34, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TSEN15 CLP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9894 | BioGRID | 2241529 | |
| TSEN15 CLP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9999 | BioGRID | 3092178 | |
| CLP1 TSEN15 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3162579 |
Curated By
- BioGRID