DCTN1
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear division [NAS]
- nervous system development [NAS]
- retrograde transport, endosome to Golgi [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BBS4
Gene Ontology Biological Process
- adult behavior [ISS]
- brain morphogenesis [ISS]
- centrosome organization [IMP]
- cerebral cortex development [ISS]
- cilium assembly [ISS]
- cilium morphogenesis [ISS]
- dendrite development [ISS]
- fat cell differentiation [ISS]
- heart looping [ISS]
- hippocampus development [ISS]
- intracellular transport [ISS]
- maintenance of protein location in nucleus [IGI]
- melanosome transport [ISS]
- metabolic process [IMP]
- microtubule anchoring at centrosome [IMP]
- microtubule cytoskeleton organization [ISS]
- mitotic cytokinesis [IMP]
- negative regulation of appetite by leptin-mediated signaling pathway [ISS]
- neural tube closure [ISS]
- nonmotile primary cilium assembly [ISS]
- photoreceptor cell maintenance [ISS]
- positive regulation of cilium assembly [ISS]
- protein localization to centrosome [IMP]
- protein localization to organelle [ISS]
- regulation of cilium beat frequency involved in ciliary motility [ISS]
- regulation of cytokinesis [IMP]
- regulation of lipid metabolic process [ISS]
- retina homeostasis [ISS]
- retinal rod cell development [ISS]
- sensory perception of smell [ISS]
- sensory processing [TAS]
- spermatid development [ISS]
- striatum development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.
BBS4 is one of several proteins that cause Bardet-Biedl syndrome (BBS), a multisystemic disorder of genetic and clinical complexity. Here we show that BBS4 localizes to the centriolar satellites of centrosomes and basal bodies of primary cilia, where it functions as an adaptor of the p150(glued) subunit of the dynein transport machinery to recruit PCM1 (pericentriolar material 1 protein) and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BBS4 DCTN1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
| BBS4 DCTN1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID