NLRC4
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- activation of innate immune response [ISS]
- defense response to bacterium [IDA]
- detection of bacterium [IDA]
- inflammatory response [ISS]
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA]
- innate immune response [IBA, TAS]
- interleukin-1 beta secretion [IDA]
- negative regulation of apoptotic process [IBA]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of apoptotic process [IDA]
- protein homooligomerization [ISS]
- protein ubiquitination [IBA]
- pyroptosis [ISS]
- regulation of neuron apoptotic process [IBA]
- regulation of signal transduction [IBA]
- spindle assembly involved in mitosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
XK
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.
Proteins of the NACHT [NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E (incompatibility locus protein from Podospora anserina) and TP1 (telomerase-associated protein)] family may serve as critical pathogen-sensing and signal-transducing molecules within the innate immune system. In the present paper, we show that CLAN [CARD (caspase-recruitment domain), LRR (leucine-rich repeat) and NACHT domain-containing protein], a NACHT-containing ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID