A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Roles of the novel coiled-coil protein Rng10 in septum formation during fission yeast cytokinesis.

Liu Y, Lee IJ, Sun M, Lower CA, Runge KW, Ma J, Wu JQ

Rho GAPs are important regulators of Rho GTPases, which are involved in various steps of cytokinesis and other processes. However, regulation of Rho-GAP cellular localization and function is not fully understood. Here we report the characterization of a novel coiled-coil protein Rng10 and its relationship with the Rho-GAP Rga7 in fission yeast. Both rng10Î” and rga7Î” result in defective septum ... [more]

Mol. Biol. Cell Aug. 15, 2016; 27(16);2528-41 [Pubmed: 27385337]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
RGA7 MYO2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Arasada R (2015)	Low	-	BioGRID	1519631
RGA7 MYO2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Liu Y (2016)	Low	-	PomBase	-

Curated By

PomBase

Interaction Summary

RGA7

Gene Ontology Biological Process

Gene Ontology Molecular Function

Rho GTPase activator activity [IMP, ISO]

Gene Ontology Cellular Component

MYO2