SOCS3
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- cytokine-mediated signaling pathway [IBA, TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of JAK-STAT cascade [IBA]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of protein kinase activity [TAS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
IRF7
Gene Ontology Biological Process
- MDA-5 signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cellular response to DNA damage stimulus [TAS]
- cytokine-mediated signaling pathway [TAS]
- establishment of viral latency [TAS]
- innate immune response [TAS]
- interferon-alpha production [ISS]
- interferon-beta production [ISS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of macrophage apoptotic process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- positive regulation of interferon-alpha production [IDA, TAS]
- positive regulation of interferon-beta production [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of type I interferon production [TAS]
- regulation of MyD88-dependent toll-like receptor signaling pathway [ISS]
- regulation of MyD88-independent toll-like receptor signaling pathway [ISS]
- regulation of adaptive immune response [IDA]
- regulation of immune response [TAS]
- regulation of monocyte differentiation [TAS]
- regulation of type I interferon production [TAS]
- response to virus [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transcription from RNA polymerase II promoter [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells.
Type I IFN production of plasmacytoid dendritic cells (pDCs) triggered by TLR-signaling is an essential part of antiviral responses and autoimmune reactions. Although it was well-documented that members of the cytokine signaling (SOCS) family regulate TLR-signaling, the mechanism of how SOCS proteins regulate TLR7-mediated type I IFN production has not been elucidated yet. In this article, we show that TLR7 ... [more]
Throughput
- Low Throughput
Additional Notes
- in vitro ubiquitination experiments were performed with a commercial ubiquitin conjugation kit with un-specified E1 and E2 activities in addition to proteins purified from cell lysates, including the substrate IRF7 as well as one of SOCS1 or SOCS3 as E3 proteins
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SOCS3 IRF7 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IRF7 SOCS3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IRF7 SOCS3 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID