VLDLR
Gene Ontology Biological Process
- glycoprotein transport [IDA]
- memory [TAS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- nervous system development [TAS]
- positive regulation of dendrite development [ISS]
- receptor-mediated endocytosis [IDA]
- reelin-mediated signaling pathway [ISS]
- signal transduction [TAS]
- very-low-density lipoprotein particle clearance [IDA]
Gene Ontology Molecular Function- apolipoprotein binding [IDA, ISS]
- calcium-dependent protein binding [IPI]
- glycoprotein binding [IPI]
- glycoprotein transporter activity [IDA]
- low-density lipoprotein receptor activity [TAS]
- protein binding [IPI]
- reelin receptor activity [ISS]
- very-low-density lipoprotein particle binding [IDA]
- very-low-density lipoprotein particle receptor activity [IDA]
- apolipoprotein binding [IDA, ISS]
- calcium-dependent protein binding [IPI]
- glycoprotein binding [IPI]
- glycoprotein transporter activity [IDA]
- low-density lipoprotein receptor activity [TAS]
- protein binding [IPI]
- reelin receptor activity [ISS]
- very-low-density lipoprotein particle binding [IDA]
- very-low-density lipoprotein particle receptor activity [IDA]
Gene Ontology Cellular Component
CANX
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- clathrin-mediated endocytosis [ISS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [TAS]
- protein secretion [TAS]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Degradation routes of trafficking-defective VLDLR mutants associated with Dysequilibrium syndrome.
Low density lipoprotein receptor (LDLR) family members are involved in signaling in the developing brain. Previously we have reported that missense mutations in the Very Low Density Lipoprotein Receptor gene (VLDLR), causing Dysequilibrium syndrome (DES), disrupt ligand-binding, due to endoplasmic reticulum (ER) retention of the mutants. We explored the degradation routes of these VLDLR mutants in cultured cells. Our results ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID