BAIT
ESR2
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
estrogen receptor 2 (ER beta)
GO Process (10)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cell-cell signaling [TAS]
- extracellular negative regulation of signal transduction [NAS]
- gene expression [TAS]
- intracellular estrogen receptor signaling pathway [TAS]
- negative regulation of cell growth [NAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- regulation of transcription, DNA-templated [TAS]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [TAS]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [TAS]
- estrogen response element binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- receptor antagonist activity [NAS]
- sequence-specific DNA binding transcription factor activity [TAS]
- steroid binding [ISS, TAS]
- steroid hormone receptor activity [TAS]
- transcription coactivator activity [TAS]
- DNA binding [TAS]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [TAS]
- estrogen response element binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- receptor antagonist activity [NAS]
- sequence-specific DNA binding transcription factor activity [TAS]
- steroid binding [ISS, TAS]
- steroid hormone receptor activity [TAS]
- transcription coactivator activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
NOTCH2
AGS2, HJCYS, hN2
notch 2
GO Process (22)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling involved in heart development [IC]
- Notch signaling pathway [TAS]
- apoptotic process [TAS]
- atrial septum morphogenesis [IMP]
- bone remodeling [IMP]
- cell cycle arrest [IDA]
- cell fate determination [TAS]
- cell growth [IDA]
- gene expression [TAS]
- hemopoiesis [TAS]
- intracellular receptor signaling pathway [TAS]
- multicellular organismal development [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell proliferation [IDA]
- nervous system development [NAS]
- organ morphogenesis [IEP]
- positive regulation of Ras protein signal transduction [IDA]
- pulmonary valve morphogenesis [IMP]
- regulation of transcription, DNA-templated [TAS]
- stem cell maintenance [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells.
The nuclear receptor estrogen receptor 2 (ESR2, ERβ) modulates cancer cell proliferation and tumor growth, exerting an oncosuppressive role in breast cancer (BC). Interaction proteomics by tandem affinity purification coupled to mass spectrometry was previously applied in BC cells to identify proteins acting in concert with ERβ to control key cellular functions, including gene transcription, RNA splicing and post-transcriptional mRNA ... [more]
Sci Data Dec. 06, 2017; 5();180031 [Pubmed: 29509190]
Throughput
- High Throughput
Curated By
- BioGRID