BAIT

PRE4

proteasome core particle subunit beta 7, L000001486, YFR050C
Beta 7 subunit of the 20S proteasome
UPS Project
Saccharomyces cerevisiae (S288c)
PREY

SAR1

Arf family GTPase SAR1, L000001801, YPL218W
GTPase, GTP-binding protein of the ARF family; component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity helping in vesicle formation
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Lethality

A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.

Publication

The proteasomal substrate Stm1 participates in apoptosis-like cell death in yeast.

Ligr M, Velten I, Froehlich E, Madeo F, Ledig M, Froehlich KU, Wolf DH, Hilt W

We have identified the yeast gene STM1 in an overexpression screen for new proteasomal substrates. Stm1 is unstable in wild-type cells and stabilized in cells with defective proteasomal activity and thus a bona fide substrate of the proteasome. It is localized in the perinuclear region and is required for growth in the presence of mutagens. Overexpression in cells with impaired ... [more]

Mol. Biol. Cell Aug. 01, 2001; 12(8);2422-32 [Pubmed: 11514626]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • in pre1 background

Curated By

  • BioGRID