BAIT
ESR2
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
estrogen receptor 2 (ER beta)
GO Process (10)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cell-cell signaling [TAS]
- extracellular negative regulation of signal transduction [NAS]
- gene expression [TAS]
- intracellular estrogen receptor signaling pathway [TAS]
- negative regulation of cell growth [NAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- regulation of transcription, DNA-templated [TAS]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [TAS]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [TAS]
- estrogen response element binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- receptor antagonist activity [NAS]
- sequence-specific DNA binding transcription factor activity [TAS]
- steroid binding [ISS, TAS]
- steroid hormone receptor activity [TAS]
- transcription coactivator activity [TAS]
- DNA binding [TAS]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [TAS]
- estrogen response element binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- receptor antagonist activity [NAS]
- sequence-specific DNA binding transcription factor activity [TAS]
- steroid binding [ISS, TAS]
- steroid hormone receptor activity [TAS]
- transcription coactivator activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
BAG6
BAG-6, BAT3, D6S52E, G3, DADB-70P7.10-021
BCL2-associated athanogene 6
GO Process (14)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- brain development [ISS]
- embryo development [ISS]
- internal peptidyl-lysine acetylation [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- kidney development [ISS]
- lung development [ISS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- negative regulation of proteolysis [ISS]
- protein stabilization [ISS]
- spermatogenesis [ISS]
- synaptonemal complex assembly [ISS]
- tail-anchored membrane protein insertion into ER membrane [IDA]
- ubiquitin-dependent protein catabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells.
The nuclear receptor estrogen receptor 2 (ESR2, ERβ) modulates cancer cell proliferation and tumor growth, exerting an oncosuppressive role in breast cancer (BC). Interaction proteomics by tandem affinity purification coupled to mass spectrometry was previously applied in BC cells to identify proteins acting in concert with ERβ to control key cellular functions, including gene transcription, RNA splicing and post-transcriptional mRNA ... [more]
Sci Data Dec. 06, 2017; 5();180031 [Pubmed: 29509190]
Throughput
- High Throughput
Curated By
- BioGRID