ARNT
Gene Ontology Biological Process
- cell differentiation [IMP]
- embryonic placenta development [IMP]
- intracellular receptor signaling pathway [IMP]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of protein sumoylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of nucleic acid-templated transcription [IPI]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- regulation of transcription, DNA-templated [TAS]
- response to hypoxia [IDA, ISO]
- response to toxic substance [TAS]
Gene Ontology Molecular Function- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
NPAS4
Gene Ontology Biological Process
- cellular response to acid chemical [IMP]
- cellular response to corticosterone stimulus [IDA]
- cellular response to stress [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of inhibitory postsynaptic membrane potential [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region DNA binding [IDA]
- protein heterodimerization activity [IPI, ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region DNA binding [IDA]
- protein heterodimerization activity [IPI, ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
The neuronal PAS domain proteins NPAS1 and NPAS3 are members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked to a variety of human psychiatric disorders including schizophrenia, autism spectrum disorders and bipolar disease. NPAS1 and NPAS3 must each heterodimerize with the aryl hydrocarbon receptor nuclear translocator (ARNT), to form functional transcription complexes capable of DNA binding ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID