BAIT
MECP2
AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT
methyl CpG binding protein 2
GO Process (2)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLP1
CG16738, Dmel\CG16738, Dmslp1, FD6, FoxG, SLP, Slp-1, l(2)05965, sko1, slp-2, Dmel_CG16738
sloppy paired 1
GO Process (23)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- anterior/posterior axis specification, embryo [NAS]
- axon midline choice point recognition [IBA]
- blastoderm segmentation [TAS]
- dorsal/ventral pattern formation [IBA]
- embryo development ending in birth or egg hatching [IBA]
- heart development [TAS]
- heart formation [IMP]
- mesoderm formation [TAS]
- negative regulation of neuron differentiation [IBA]
- negative regulation of transcription from RNA polymerase II promoter [IBA, IDA]
- neuron fate specification [IBA]
- nonmotile primary cilium assembly [IBA]
- positive regulation of cell cycle [IBA]
- positive regulation of neuroblast proliferation [IBA]
- positive regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of gene expression [IMP]
- regulation of mitotic cell cycle [IBA]
- regulation of sequence-specific DNA binding transcription factor activity [IBA]
- regulation of transcription, DNA-templated [ISS]
- segment specification [NAS]
- specification of segmental identity, head [IEP, IGI, IMP]
- specification of segmental identity, mandibular segment [NAS]
- tissue development [IBA]
Gene Ontology Molecular Function- DNA binding, bending [IBA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA, IDA]
- double-stranded DNA binding [IBA]
- enhancer sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription factor binding [IBA]
- DNA binding, bending [IBA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA, IDA]
- double-stranded DNA binding [IBA]
- enhancer sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription factor binding [IBA]
Drosophila melanogaster
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Apoptotic Activity of MeCP2 Is Enhanced by C-Terminal Truncating Mutations.
Methyl-CpG binding protein 2 (MeCP2) is a widely abundant, multifunctional protein most highly expressed in post-mitotic neurons. Mutations causing Rett syndrome and related neurodevelopmental disorders have been identified along the entire MECP2 locus, but symptoms vary depending on mutation type and location. C-terminal mutations are prevalent, but little is known about the function of the MeCP2 C-terminus. We employ the ... [more]
PLoS ONE Jul. 22, 2016; 11(7);e0159632 [Pubmed: 27442528]
Throughput
- Low Throughput
Curated By
- BioGRID