CBF1
Gene Ontology Biological Process
- chromatin remodeling [IDA, IMP]
- chromosome segregation [IGI, IMP]
- negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription from RNA polymerase II promoter in response to methionine [IMP]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [IMP, IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II repressing transcription factor binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IMP]
- centromeric DNA binding [IDA]
- sequence-specific DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IMP, IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II repressing transcription factor binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IMP]
- centromeric DNA binding [IDA]
- sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
OKP1
Gene Ontology Biological Process
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
The kinetochore module Okp1CENP-Q/Ame1CENP-U is a reader for N-terminal modifications on the centromeric histone Cse4CENP-A.
Kinetochores are supramolecular assemblies that link centromeres to microtubules for sister chromatid segregation in mitosis. For this, the inner kinetochore CCAN/Ctf19 complex binds to centromeric chromatin containing the histone variant CENP-A, but whether the interaction of kinetochore components to centromeric nucleosomes is regulated by posttranslational modifications is unknown. Here, we investigated how methylation of arginine 37 (R37Me) and acetylation of ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: heat sensitivity (APO:0000147)
Additional Notes
- genetic complex
- mutation of okp1 rescues temperature sensitivity in a cbf1/cse4 double mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CBF1 OKP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2444 | BioGRID | 2052254 |
Curated By
- BioGRID