DAXX
Gene Ontology Biological Process
- PML body organization [ISO]
- androgen receptor signaling pathway [ISO]
- apoptotic signaling pathway [IGI]
- chromatin remodeling [ISO]
- mitotic cytokinesis [IMP]
- negative regulation of myotube differentiation [ISO]
- negative regulation of nucleic acid-templated transcription [TAS]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- nucleosome assembly [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IDA, IGI]
- positive regulation of histone phosphorylation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of protein ubiquitination [ISO]
- regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- enzyme binding [ISO]
- histone binding [IDA, ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase activator activity [ISO]
- protein kinase binding [ISO]
- transcription coactivator activity [IDA]
- transcription corepressor activity [ISO, TAS]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- androgen receptor binding [ISO]
- enzyme binding [ISO]
- histone binding [IDA, ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase activator activity [ISO]
- protein kinase binding [ISO]
- transcription coactivator activity [IDA]
- transcription corepressor activity [ISO, TAS]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
ATRX
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA damage response, signal transduction by p53 class mediator [IMP]
- DNA replication-independent nucleosome assembly [ISO]
- Sertoli cell development [IMP]
- cellular response to hydroxyurea [IMP]
- chromatin remodeling [ISO]
- forebrain development [IMP]
- negative regulation of telomeric RNA transcription from RNA pol II promoter [IMP]
- nucleosome assembly [ISO]
- positive regulation of nuclear cell cycle DNA replication [IMP]
- positive regulation of telomere maintenance [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- replication fork processing [IMP]
- seminiferous tubule development [IMP]
- spermatogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres.
The promyelocytic leukemia protein (PML) is expressed in most normal human tissues and forms nuclear bodies (NBs) that have roles in gene regulation and cellular processes such as DNA repair, cell cycle control, and cell fate decisions. Using murine C2C12 myoblasts, we demonstrate that activation of skeletal muscle differentiation results in loss of PML and PML NBs prior to myotube ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATRX DAXX | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID