BAIT
SOSTDC1
ECTODIN, USAG1, CDA019
sclerostin domain containing 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
BMP2
BDA2, BMP2A
bone morphogenetic protein 2
GO Process (79)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IEP, IMP, TAS]
- BMP signaling pathway involved in heart induction [IDA]
- Notch signaling pathway [ISS]
- SMAD protein signal transduction [IDA]
- activation of MAPK activity [IDA]
- atrioventricular valve morphogenesis [ISS]
- bone mineralization [ISS]
- bone mineralization involved in bone maturation [IDA]
- branching involved in ureteric bud morphogenesis [ISS]
- cardiac epithelial to mesenchymal transition [IDA]
- cardiac muscle cell differentiation [IMP]
- cardiac muscle tissue morphogenesis [ISS]
- cardiocyte differentiation [IDA, IMP]
- cell fate commitment [ISS]
- cell-cell signaling [TAS]
- cellular response to BMP stimulus [IDA]
- chondrocyte differentiation [IDA]
- corticotropin hormone secreting cell differentiation [ISS]
- embryo development [ISS]
- embryonic heart tube anterior/posterior pattern specification [ISS]
- endocardial cushion morphogenesis [ISS]
- epithelial to mesenchymal transition [IDA]
- extracellular matrix organization [TAS]
- heart development [ISS]
- in utero embryonic development [ISS]
- inflammatory response [ISS]
- inner ear development [ISS]
- mesenchymal cell differentiation [IDA]
- mesenchymal cell proliferation involved in ureteric bud development [ISS]
- mesenchyme development [IMP]
- negative regulation of Wnt signaling pathway involved in heart development [IDA]
- negative regulation of aldosterone biosynthetic process [IDA]
- negative regulation of calcium-independent cell-cell adhesion [IDA]
- negative regulation of canonical Wnt signaling pathway [IEP]
- negative regulation of cardiac muscle cell differentiation [IDA]
- negative regulation of cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cortisol biosynthetic process [IDA]
- negative regulation of insulin-like growth factor receptor signaling pathway [IDA]
- negative regulation of steroid biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- odontogenesis of dentin-containing tooth [ISS]
- organ morphogenesis [ISS]
- osteoblast differentiation [IDA]
- pathway-restricted SMAD protein phosphorylation [IDA]
- pericardium development [ISS]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of Wnt signaling pathway by BMP signaling pathway [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of astrocyte differentiation [ISS]
- positive regulation of bone mineralization [IDA]
- positive regulation of cartilage development [IDA]
- positive regulation of cell migration [ISS]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of fat cell differentiation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of neuron differentiation [ISS]
- positive regulation of odontogenesis [ISS]
- positive regulation of ossification [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of osteoblast proliferation [ISS]
- positive regulation of p38MAPK cascade [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, IMP]
- positive regulation of phosphatase activity [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of transcription, DNA-templated [IDA]
- response to hypoxia [ISS]
- skeletal system development [TAS]
- telencephalon development [IDA]
- telencephalon regionalization [ISS]
- thyroid-stimulating hormone-secreting cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.
Bone morphogenetic proteins (BMPs) play critical roles in cellular proliferation, differentiation, and programmed cell death in multiple tissues. An increasing body of recent evidence has suggested that classes of molecules collectively termed BMP antagonists play important roles for the local regulation of BMP actions by binding BMPs and neutralizing their activities. Uterine sensitization-associated gene-1 (USAG-1) was previously reported as a ... [more]
Biochem. Biophys. Res. Commun. Apr. 02, 2004; 316(2);490-500 [Pubmed: 15020244]
Throughput
- Low Throughput
Curated By
- BioGRID