BAIT
HEXIM1
CLP1, EDG1, HIS1, MAQ1
hexamethylene bis-acetamide inducible 1
GO Process (3)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
KIF5B
HEL-S-61, KINH, KNS, KNS1, UKHC
kinesin family member 5B
GO Process (10)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- axon guidance [IBA]
- cellular protein metabolic process [TAS]
- cytoskeleton-dependent intracellular transport [IBA]
- microtubule-based movement [IBA]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- positive regulation of potassium ion transport [IDA]
- regulation of membrane potential [IDA]
- stress granule disassembly [ISS]
- vesicle transport along microtubule [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.
The HIV-1 Tat protein hijacks P-TEFb kinase to activate paused RNA polymerase II (RNAP II) at the viral promoter. Tat binds additional host factors, but it is unclear how they regulate RNAP II elongation. Here, we identify the cytoplasmic ubiquitin ligase UBE2O as critical for Tat transcriptional activity. Tat hijacks UBE2O to ubiquitinate the P-TEFb kinase inhibitor HEXIM1 of the ... [more]
Elife May. 30, 2018; 7(); [Pubmed: 29845934]
Throughput
- High Throughput
Curated By
- BioGRID