CXCR2
Gene Ontology Biological Process
- cell surface receptor signaling pathway [IDA]
- cellular defense response [IDA]
- chemokine-mediated signaling pathway [IDA]
- chemotaxis [IDA]
- dendritic cell chemotaxis [TAS]
- inflammatory response [TAS]
- interleukin-8-mediated signaling pathway [IDA]
- neutrophil activation [IDA]
- neutrophil chemotaxis [IDA]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- positive regulation of cell proliferation [IDA]
- receptor internalization [IDA]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB11FIP2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis.
Agonist-stimulated internalization followed by recycling to the cell membrane play an important role in fine-tuning the activity of chemokine receptors. Because the recycling of chemokine receptors is critical for the reestablishment of the cellular responsiveness to ligand, it is crucial to understand the mechanisms underlying the receptor recycling and resensitization. In the present study, we have demonstrated that the chemokine ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID