BAIT

STX1A

HPC-1, P35-1, STX1, SYN1A
syntaxin 1A (brain)
Homo sapiens
PREY

SCNN1G

BESC3, ENaCg, ENaCgamma, PHA1, SCNEG
sodium channel, non-voltage-gated 1, gamma subunit
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

ENaC subunit-subunit interactions and inhibition by syntaxin 1A.

Berdiev BK, Jovov B, Tucker WC, Naren AP, Fuller CM, Chapman ER, Benos DJ

Amiloride-sensitive epithelial Na(+) channels (ENaCs) are subject to modulation by many factors. Recent data have also linked the N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery to this regulation of ENaC, but the molecular mechanisms that underlie this modulation are poorly understood. In this study, we demonstrate that syntaxin 1A physically interacts with ENaC and functionally regulates ENaC activity. Syntaxin 1A ... [more]

Am. J. Physiol. Renal Physiol. Jun. 01, 2004; 286(6);F1100-6 [Pubmed: 14996668]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
STX1A SCNN1G
Affinity Capture-Western
Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Low-BioGRID
-

Curated By

  • BioGRID