BAIT
NGF
Beta-NGF, HSAN5, NGFB
nerve growth factor (beta polypeptide)
GO Process (21)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- activation of phospholipase C activity [TAS]
- apoptotic signaling pathway [TAS]
- cell-cell signaling [IBA]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell cycle [TAS]
- negative regulation of neuron apoptotic process [IBA]
- nerve growth factor processing [TAS]
- neuron projection morphogenesis [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of axonogenesis [TAS]
- positive regulation of gene expression [IMP]
- regulation of axonogenesis [TAS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- regulation of neuron differentiation [IBA]
- small GTPase mediated signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NGFR
CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR
nerve growth factor receptor
GO Process (14)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- circadian regulation of gene expression [ISS]
- glucose homeostasis [ISS]
- intracellular protein transport [ISS]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of axonogenesis [TAS]
- negative regulation of cell cycle [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of axonogenesis [TAS]
- regulation of axonogenesis [TAS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- regulation of glucose import in response to insulin stimulus [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Sortilin is essential for proNGF-induced neuronal cell death.
Sortilin (approximately 95 kDa) is a member of the recently discovered family of Vps10p-domain receptors, and is expressed in a variety of tissues, notably brain, spinal cord and muscle. It acts as a receptor for neurotensin, but predominates in regions of the nervous system that neither synthesize nor respond to this neuropeptide, suggesting that sortilin has additional roles. Sortilin is ... [more]
Nature Feb. 26, 2004; 427(6977);843-8 [Pubmed: 14985763]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID