MYOCD
Gene Ontology Biological Process
- cardiac muscle cell differentiation [ISS]
- cardiocyte differentiation [NAS]
- negative regulation of beta-amyloid clearance [IMP]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of skeletal muscle cell differentiation [IDA]
- positive regulation of cardiac muscle cell differentiation [IDA]
- positive regulation of cardiac vascular smooth muscle cell differentiation [ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of smooth muscle cell differentiation [IDA]
- positive regulation of smooth muscle contraction [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of histone acetylation [ISS]
- regulation of smooth muscle cell differentiation [TAS]
- response to hypoxia [IEP]
- smooth muscle cell differentiation [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [ISS]
- core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
- transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [ISS]
- core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
- transcription factor binding [IPI]
MKL1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells.
The SAP domain transcription factor myocardin plays a critical role in the transcriptional program regulating smooth muscle cell differentiation. In this report, we describe the capacity of myocardin to physically associate with megakaryoblastic leukemia factor-1 (MKL1) and characterize the function of MKL1 in smooth muscle cells (SMCs). The MKL1 gene is expressed in most human tissues and myocardin and MKL ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID