BAIT
DYNLL1
DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1
dynein, light chain, LC8-type 1
GO Process (11)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- actin cytoskeleton organization [TAS]
- anatomical structure morphogenesis [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- apoptotic process [TAS]
- female gamete generation [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic cell cycle [TAS]
- negative regulation of phosphorylation [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GLUL
Glns
glutamate-ammonia ligase
GO Process (11)
GO Function (7)
GO Component (14)
Gene Ontology Biological Process
- ammonia assimilation cycle [IDA, TAS]
- cell proliferation [ISO]
- cellular response to starvation [ISO]
- glutamate metabolic process [IDA]
- glutamine biosynthetic process [IDA]
- neurotransmitter metabolic process [TAS]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- protein homooligomerization [IDA]
- response to glucose [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon terminus [IDA]
- cell body [ISO]
- cell projection [IDA]
- cytoplasm [IDA, ISO]
- extracellular vesicular exosome [ISO]
- glial cell projection [ISO]
- intracellular membrane-bounded organelle [IDA]
- mitochondrion [ISO]
- myelin sheath [ISO]
- neuron projection [IDA]
- nucleus [ISO]
- perikaryon [IDA]
- protein complex [IDA]
- rough endoplasmic reticulum [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic identification of brain proteins that interact with dynein light chain LC8.
Cytoplasmic dynein is a large minus end-directed microtubule motor that translocates cargos towards the minus end of microtubules. Light chain 8 of the dynein machinery (LC8) has been reported to interact with a large variety of proteins that possess K/RSTQT or GIQVD motifs in their sequence, hence permitting their transport in a retrograde manner. Yeast two-hybrid analysis has revealed that ... [more]
Proteomics Feb. 01, 2004; 4(2);339-46 [Pubmed: 14760703]
Throughput
- Low Throughput
Curated By
- BioGRID