BAIT
DYNLL1
DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1
dynein, light chain, LC8-type 1
GO Process (11)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- actin cytoskeleton organization [TAS]
- anatomical structure morphogenesis [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- apoptotic process [TAS]
- female gamete generation [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic cell cycle [TAS]
- negative regulation of phosphorylation [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VIM
vimentin
GO Process (21)
GO Function (12)
GO Component (16)
Gene Ontology Biological Process
- Bergmann glial cell differentiation [ISO]
- SMAD protein signal transduction [ISO]
- aging [IEP]
- astrocyte development [ISO]
- cellular response to fibroblast growth factor stimulus [IEP]
- decidualization [IEP]
- fat cell differentiation [IEP]
- intermediate filament organization [ISO]
- intermediate filament-based process [ISO]
- lens fiber cell development [ISO]
- negative regulation of neuron projection development [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of glial cell proliferation [IMP]
- regulation of Schwann cell migration [IDA]
- regulation of axonogenesis [IDA]
- response to estradiol [IEP]
- response to radiation [IEP]
- response to selenium ion [IEP]
- response to vitamin D [IEP]
- response to zinc ion [IEP]
- skeletal muscle tissue regeneration [IEP]
Gene Ontology Molecular Function- double-stranded RNA binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- kinase binding [IPI]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [IDA]
- scaffold protein binding [ISO]
- structural constituent of cytoskeleton [ISO, ISS]
- structural constituent of eye lens [ISO]
- structural molecule activity [ISO, TAS]
- double-stranded RNA binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- kinase binding [IPI]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [IDA]
- scaffold protein binding [ISO]
- structural constituent of cytoskeleton [ISO, ISS]
- structural constituent of eye lens [ISO]
- structural molecule activity [ISO, TAS]
Gene Ontology Cellular Component
- axon [IDA]
- cell body [IDA]
- cell leading edge [ISO]
- cell projection [IDA, ISO]
- cytoplasm [IDA, ISO, ISS]
- cytoskeleton [IDA, ISO]
- cytosol [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intermediate filament [ISO, ISS]
- intermediate filament cytoskeleton [ISO]
- neuron projection [ISO]
- perinuclear region of cytoplasm [IDA]
- peroxisome [ISO]
- plasma membrane [ISO]
- type III intermediate filament [TAS]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic identification of brain proteins that interact with dynein light chain LC8.
Cytoplasmic dynein is a large minus end-directed microtubule motor that translocates cargos towards the minus end of microtubules. Light chain 8 of the dynein machinery (LC8) has been reported to interact with a large variety of proteins that possess K/RSTQT or GIQVD motifs in their sequence, hence permitting their transport in a retrograde manner. Yeast two-hybrid analysis has revealed that ... [more]
Proteomics Feb. 01, 2004; 4(2);339-46 [Pubmed: 14760703]
Throughput
- Low Throughput
Curated By
- BioGRID