BAIT
DYNLL1
DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1
dynein, light chain, LC8-type 1
GO Process (11)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- actin cytoskeleton organization [TAS]
- anatomical structure morphogenesis [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- apoptotic process [TAS]
- female gamete generation [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic cell cycle [TAS]
- negative regulation of phosphorylation [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PARD3
Par3
par-3 family cell polarity regulator
GO Process (13)
GO Function (5)
GO Component (15)
Gene Ontology Biological Process
- apical constriction [ISO]
- centrosome localization [ISO]
- establishment of epithelial cell polarity [IMP]
- establishment or maintenance of epithelial cell apical/basal polarity [NAS]
- microtubule cytoskeleton organization [ISO]
- myelination in peripheral nervous system [ISO, ISS]
- negative regulation of peptidyl-threonine phosphorylation [ISO, ISS]
- positive regulation of myelination [ISO, ISS]
- protein targeting to membrane [IDA]
- regulation of actin filament-based process [ISO]
- regulation of cellular localization [IMP]
- tight junction assembly [IMP]
- wound healing, spreading of cells [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [ISO]
- adherens junction [ISO]
- apical part of cell [ISO]
- axonal growth cone [IDA]
- cell cortex [ISO]
- cell junction [ISO]
- cell-cell adherens junction [ISO]
- cell-cell junction [IDA, ISO]
- cytoplasm [ISO]
- internode region of axon [ISO, ISS]
- lateral loop [ISO]
- neuronal cell body [IDA]
- protein complex [IDA, ISO]
- spindle [ISO]
- tight junction [ISO, ISS]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic identification of brain proteins that interact with dynein light chain LC8.
Cytoplasmic dynein is a large minus end-directed microtubule motor that translocates cargos towards the minus end of microtubules. Light chain 8 of the dynein machinery (LC8) has been reported to interact with a large variety of proteins that possess K/RSTQT or GIQVD motifs in their sequence, hence permitting their transport in a retrograde manner. Yeast two-hybrid analysis has revealed that ... [more]
Proteomics Feb. 01, 2004; 4(2);339-46 [Pubmed: 14760703]
Throughput
- Low Throughput
Curated By
- BioGRID