BAIT
DYNLL1
DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1
dynein, light chain, LC8-type 1
GO Process (11)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- actin cytoskeleton organization [TAS]
- anatomical structure morphogenesis [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- apoptotic process [TAS]
- female gamete generation [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic cell cycle [TAS]
- negative regulation of phosphorylation [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DNM2
DYIIAAB
dynamin 2
GO Process (14)
GO Function (9)
GO Component (19)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IMP]
- GTP catabolic process [TAS]
- cellular response to X-ray [IEP]
- cilium morphogenesis [IMP]
- endocytosis [TAS]
- macropinocytosis [IMP]
- negative regulation of membrane tubulation [ISO]
- neuron projection morphogenesis [IMP]
- receptor internalization [ISO]
- receptor-mediated endocytosis [IDA, IMP]
- regulation of axon extension [IMP]
- response to light stimulus [IEP]
- spermatogenesis [IEP]
- transferrin transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- cell junction [IDA]
- centrosome [IDA]
- clathrin-coated endocytic vesicle [IDA]
- coated pit [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [IDA]
- lamellipodium [IDA]
- microtubule [ISO]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- photoreceptor inner segment [ISO]
- plasma membrane [IDA, TAS]
- postsynaptic membrane [ISO, ISS]
- protein complex [IDA]
- ruffle membrane [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic identification of brain proteins that interact with dynein light chain LC8.
Cytoplasmic dynein is a large minus end-directed microtubule motor that translocates cargos towards the minus end of microtubules. Light chain 8 of the dynein machinery (LC8) has been reported to interact with a large variety of proteins that possess K/RSTQT or GIQVD motifs in their sequence, hence permitting their transport in a retrograde manner. Yeast two-hybrid analysis has revealed that ... [more]
Proteomics Feb. 01, 2004; 4(2);339-46 [Pubmed: 14760703]
Throughput
- Low Throughput
Curated By
- BioGRID