FYN
Gene Ontology Biological Process
- T cell activation [IBA]
- T cell receptor signaling pathway [IBA, ISO]
- activated T cell proliferation [ISO]
- cell differentiation [IBA]
- cell migration [IBA]
- cell surface receptor signaling pathway [ISO]
- cellular response to growth factor stimulus [IEP]
- cellular response to peptide hormone stimulus [IEP]
- cellular response to platelet-derived growth factor stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [ISO]
- central nervous system development [IBA]
- dendrite morphogenesis [ISO]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- forebrain development [ISO]
- innate immune response [IBA]
- ionotropic glutamate receptor signaling pathway [TAS]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of protein catabolic process [ISO]
- neuron migration [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein localization to nucleus [ISO]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [ISO]
- regulation of cell proliferation [IBA]
- regulation of cell shape [ISO]
- response to drug [IEP]
- response to ethanol [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- CD4 receptor binding [IPI]
- CD8 receptor binding [IPI]
- G-protein coupled receptor binding [ISO]
- T cell receptor binding [IDA]
- ephrin receptor binding [ISO]
- glycoprotein binding [IPI, ISO]
- growth factor receptor binding [ISO]
- ion channel binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase activity [IDA, ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- tubulin binding [ISO]
- CD4 receptor binding [IPI]
- CD8 receptor binding [IPI]
- G-protein coupled receptor binding [ISO]
- T cell receptor binding [IDA]
- ephrin receptor binding [ISO]
- glycoprotein binding [IPI, ISO]
- growth factor receptor binding [ISO]
- ion channel binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase activity [IDA, ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- tubulin binding [ISO]
Gene Ontology Cellular Component
STXBP1
Gene Ontology Biological Process
- axon target recognition [ISO]
- exocytosis [ISO]
- long term synaptic depression [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of synaptic transmission, GABAergic [ISO]
- neuromuscular synaptic transmission [ISO]
- neurotransmitter secretion [ISO]
- platelet aggregation [ISO]
- platelet degranulation [ISO]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of exocytosis [IMP]
- protein localization to plasma membrane [ISO]
- protein stabilization [IDA]
- regulation of synaptic vesicle priming [IMP]
- synaptic vesicle maturation [ISO]
- vesicle docking involved in exocytosis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
PTPRT regulates the interaction of Syntaxin-binding protein 1 with Syntaxin 1 through dephosphorylation of specific tyrosine residue.
PTPRT (protein tyrosine phosphatase receptor T), a brain-specific tyrosine phosphatase, has been found to regulate synaptic formation and development of hippocampal neurons, but its regulation mechanism is not yet fully understood. Here, Syntaxin-binding protein 1, a key component of synaptic vesicle fusion machinery, was identified as a possible interaction partner and an endogenous substrate of PTPRT. PTPRT interacted with Syntaxin-binding ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID