PTPRM
Gene Ontology Biological Process
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- negative regulation of angiogenesis [ISO]
- negative regulation of endothelial cell migration [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- neuron projection development [ISO]
- peptidyl-tyrosine dephosphorylation [ISO]
- positive regulation of vasodilation [ISO]
- protein dephosphorylation [ISO]
- response to drug [ISO]
- retina layer formation [ISO]
- retinal ganglion cell axon guidance [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDH2
Gene Ontology Biological Process
- blood vessel morphogenesis [ISO]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IMP, ISO]
- cell adhesion [ISO]
- cell migration [ISO]
- cell-cell adhesion mediated by cadherin [ISO, ISS]
- glial cell differentiation [ISO, ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISO]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- neuronal stem cell maintenance [ISO, ISS]
- positive regulation of MAPK cascade [ISO]
- protein heterooligomerization [IPI]
- regulation of Rho protein signal transduction [IMP]
- regulation of axonogenesis [IMP]
- regulation of myelination [IMP]
- regulation of protein localization [IMP]
- single organismal cell-cell adhesion [IDA]
- striated muscle cell differentiation [ISO]
- synapse assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [IDA]
- adherens junction [ISO]
- apical plasma membrane [ISO]
- catenin complex [ISO]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- intercalated disc [IDA, ISO]
- lamellipodium [ISO]
- membrane [IDA]
- plasma membrane [IDA]
- protein complex [IDA]
- synapse [IDA, ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Dynamic interaction of PTPmu with multiple cadherins in vivo.
There is a growing body of evidence to implicate reversible tyrosine phosphorylation as an important mechanism in the control of the adhesive function of cadherins. We previously demonstrated that the receptor protein tyrosine phosphatase PTPmu associates with the cadherin-catenin complex in various tissues and cells and, therefore, may be a component of such a regulatory mechanism (Brady-Kalnay, S. M., D.L. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID