BAIT
STX1A
HPC-1, P35-1, STX1, SYN1A
syntaxin 1A (brain)
GO Process (11)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- energy reserve metabolic process [TAS]
- glutamate secretion [TAS]
- intracellular protein transport [IBA]
- neurotransmitter secretion [TAS]
- regulation of insulin secretion [TAS]
- secretion by cell [IDA]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VPS16
hVPS16, RP11-12M19.2
vacuolar protein sorting 16 homolog (S. cerevisiae)
GO Process (3)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The interaction of mammalian Class C Vps with nSec-1/Munc18-a and syntaxin 1A regulates pre-synaptic release.
Membrane docking and fusion in neurons is a highly regulated process requiring the participation of a large number of SNAREs (soluble N-ethylmaleimide sensitive factor attachment protein receptors) and SNARE-interacting proteins. We found that mammalian Class C Vps protein complex associated specifically with nSec-1/Munc18-a, and syntaxin 1A both in vivo and in vitro. In contrast, VAMP2 and SNAP-25, other neuronal core ... [more]
Biochem. Biophys. Res. Commun. Nov. 24, 2006; 350(3);691-7 [Pubmed: 17027648]
Throughput
- Low Throughput
Curated By
- BioGRID