BAIT
STXBP1
ANC18HA, Munc18-1, NSEC1A, Sec1, Unc18-1, n-sec1, nSec1, rbSec1, rbSec1A, rbSec1B
syntaxin binding protein 1
GO Process (16)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- axon target recognition [ISO]
- exocytosis [ISO]
- long term synaptic depression [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of synaptic transmission, GABAergic [ISO]
- neuromuscular synaptic transmission [ISO]
- neurotransmitter secretion [ISO]
- platelet aggregation [ISO]
- platelet degranulation [ISO]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of exocytosis [IMP]
- protein localization to plasma membrane [ISO]
- protein stabilization [IDA]
- regulation of synaptic vesicle priming [IMP]
- synaptic vesicle maturation [ISO]
- vesicle docking involved in exocytosis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
VPS11
END1, PEP5, RNF108, hVPS11, PP3476
vacuolar protein sorting 11 homolog (S. cerevisiae)
GO Process (0)
GO Function (2)
GO Component (6)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The interaction of mammalian Class C Vps with nSec-1/Munc18-a and syntaxin 1A regulates pre-synaptic release.
Membrane docking and fusion in neurons is a highly regulated process requiring the participation of a large number of SNAREs (soluble N-ethylmaleimide sensitive factor attachment protein receptors) and SNARE-interacting proteins. We found that mammalian Class C Vps protein complex associated specifically with nSec-1/Munc18-a, and syntaxin 1A both in vivo and in vitro. In contrast, VAMP2 and SNAP-25, other neuronal core ... [more]
Biochem. Biophys. Res. Commun. Nov. 24, 2006; 350(3);691-7 [Pubmed: 17027648]
Throughput
- Low Throughput
Curated By
- BioGRID