GNAI1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- cell division [IMP]
- platelet activation [TAS]
- response to peptide hormone [ISS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PDGFRA
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cardiac myofibril assembly [ISS]
- cell activation [TAS]
- cell chemotaxis [IMP]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic digestive tract morphogenesis [ISS]
- embryonic skeletal system morphogenesis [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- luteinization [ISS]
- metanephric glomerular capillary formation [ISS]
- negative regulation of platelet activation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [IMP, TAS]
- platelet aggregation [IMP]
- platelet-derived growth factor receptor signaling pathway [IDA]
- platelet-derived growth factor receptor-alpha signaling pathway [IMP]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cell migration [IDA, IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [IMP]
- protein autophosphorylation [IDA]
- regulation of actin cytoskeleton reorganization [TAS]
- regulation of chemotaxis [IMP]
- regulation of mesenchymal stem cell differentiation [IMP]
- retina vasculature development in camera-type eye [ISS]
- wound healing [ISS]
Gene Ontology Molecular Function- platelet-derived growth factor alpha-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IDA]
- vascular endothelial growth factor binding [IPI]
- vascular endothelial growth factor-activated receptor activity [IDA]
- platelet-derived growth factor alpha-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IDA]
- vascular endothelial growth factor binding [IPI]
- vascular endothelial growth factor-activated receptor activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
microRNA-200a downregulation in human glioma leads to Gαi1 over-expression, Akt activation, and cell proliferation.
We previously identified a pivotal role for G protein α inhibitory subunit 1 (Gαi1) in mediating PI3K-Akt signaling by receptor tyrosine kinases (RTKs). Here, we examined the expression and biological function of Gαi1 in human glioma. Gαi1 mRNA and protein expression were significantly upregulated in human glioma tissues, which correlated with downregulation of an anti-Gαi1 miRNA: microRNA-200a ("miR-200a"). Forced-expression of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID