PTPRZ1
Gene Ontology Biological Process
- axonal fasciculation [ISO]
- axonogenesis [IDA]
- hematopoietic progenitor cell differentiation [IMP]
- learning or memory [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of cell-substrate adhesion [ISO]
- negative regulation of dendrite development [ISO]
- oligodendrocyte differentiation [IMP]
- peptidyl-tyrosine dephosphorylation [IMP, ISO]
- positive regulation of Schwann cell migration [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of dendrite development [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of neuron migration [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- protein dephosphorylation [ISO]
- regulation of dendrite morphogenesis [ISO]
- regulation of oligodendrocyte progenitor proliferation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IL34
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34.
Interleukin-34 (IL-34) is highly expressed in brain. IL-34 signaling via its cognate receptor, colony-stimulating factor-1 receptor (CSF-1R), is required for the development of microglia. However, the differential expression of IL-34 and the CSF-1R in brain suggests that IL-34 may signal via an alternate receptor. By IL-34 affinity chromatography of solubilized mouse brain membrane followed by mass spectrometric analysis, we identified ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
IL34 PTPRZ1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
IL34 PTPRZ1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID