BAIT

PTPRZ1

HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Homo sapiens
PREY

IL34

C16orf77, IL-34
interleukin 34
GO Process (2)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34.

Nandi S, Cioce M, Yeung YG, Nieves E, Tesfa L, Lin H, Hsu AW, Halenbeck R, Cheng HY, Gokhan S, Mehler MF, Stanley ER

Interleukin-34 (IL-34) is highly expressed in brain. IL-34 signaling via its cognate receptor, colony-stimulating factor-1 receptor (CSF-1R), is required for the development of microglia. However, the differential expression of IL-34 and the CSF-1R in brain suggests that IL-34 may signal via an alternate receptor. By IL-34 affinity chromatography of solubilized mouse brain membrane followed by mass spectrometric analysis, we identified ... [more]

J. Biol. Chem. Jul. 26, 2013; 288(30);21972-86 [Pubmed: 23744080]

Throughput

  • Low Throughput

Curated By

  • BioGRID