SLITRK5
Gene Ontology Biological Process
Gene Ontology Cellular Component
NTRK2
Gene Ontology Biological Process
- brain-derived neurotrophic factor receptor signaling pathway [IDA, ISO]
- calcium-mediated signaling using intracellular calcium source [IMP]
- central nervous system neuron development [IMP]
- cerebral cortex development [IMP]
- feeding behavior [IMP]
- glutamate secretion [IPI]
- learning [IMP]
- long-term memory [ISO]
- long-term synaptic potentiation [IMP]
- mechanoreceptor differentiation [IMP]
- negative regulation of anoikis [IDA]
- negative regulation of neuron apoptotic process [ISO]
- neuromuscular junction development [IMP]
- neuron differentiation [IMP]
- neuron migration [IMP]
- neurotrophin signaling pathway [IDA, ISO]
- oligodendrocyte differentiation [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- peripheral nervous system neuron development [IMP]
- positive regulation of MAPK cascade [ISO]
- positive regulation of axonogenesis [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of glucocorticoid receptor signaling pathway [ISO]
- positive regulation of neuron projection development [IDA]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- protein autophosphorylation [ISO]
- regulation of MAPK cascade [ISO]
- regulation of Rac GTPase activity [IDA]
- regulation of dendrite development [ISO]
- regulation of metabolic process [IMP]
- regulation of neurotransmitter secretion [ISO]
- regulation of protein kinase B signaling [IMP]
- retinal rod cell development [IMP]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- brain-derived neurotrophic factor binding [IDA, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [ISO]
- neurotrophin binding [IDA, ISO]
- neurotrophin receptor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- brain-derived neurotrophic factor binding [IDA, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [ISO]
- neurotrophin binding [IDA, ISO]
- neurotrophin receptor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- axon terminus [ISO]
- cell [IPI]
- cell surface [ISO]
- cytoplasm [ISO]
- cytosol [IDA]
- dendrite [ISO]
- dendritic spine [ISO]
- endosome [IDA]
- excitatory synapse [ISO]
- growth cone [ISO]
- integral component of plasma membrane [ISO]
- intracellular [IMP]
- neuronal cell body [ISO]
- neuronal postsynaptic density [IDA]
- perikaryon [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- postsynaptic membrane [IDA]
- presynaptic active zone [ISO]
- receptor complex [ISO]
- rough endoplasmic reticulum [ISO]
- terminal bouton [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling.
Recent studies in humans and in genetic mouse models have identified Slit- and NTRK-like family (Slitrks) as candidate genes for neuropsychiatric disorders. All Slitrk isotypes are highly expressed in the CNS, where they mediate neurite outgrowth, synaptogenesis, and neuronal survival. However, the molecular mechanisms underlying these functions are not known. Here, we report that Slitrk5 modulates brain-derived neurotrophic factor (BDNF)-dependent ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NTRK2 SLITRK5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| NTRK2 SLITRK5 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.1538 | BioGRID | 3499322 |
Curated By
- BioGRID