SLITRK5
Gene Ontology Biological Process
Gene Ontology Cellular Component
RAB11A
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA]
- astral microtubule organization [ISO]
- cytokinesis [ISO]
- establishment of protein localization to membrane [ISO]
- establishment of protein localization to organelle [ISO]
- establishment of vesicle localization [ISO]
- exocytosis [IBA]
- exosomal secretion [ISO]
- intracellular protein transport [IBA]
- melanosome transport [IMP]
- mitotic metaphase plate congression [ISO]
- multivesicular body assembly [ISO]
- neuron projection development [ISO]
- positive regulation of G2/M transition of mitotic cell cycle [ISO]
- positive regulation of axon extension [IMP]
- positive regulation of epithelial cell migration [ISO]
- protein localization to plasma membrane [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of multivesicular body size [ISO]
- regulation of protein transport [ISO]
- regulation of vesicle-mediated transport [ISO]
- spindle assembly involved in mitosis [ISO]
- vesicle-mediated transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [IDA]
- cell [IMP]
- cleavage furrow [ISO]
- cytoplasm [IDA]
- cytoplasmic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IBA]
- kinetochore microtubule [ISO]
- membrane [IDA]
- mitochondrion [IDA]
- multivesicular body [ISO]
- perinuclear region of cytoplasm [IDA]
- phagocytic vesicle [ISO]
- protein complex [ISO]
- recycling endosome [IDA, ISO]
- spindle pole [ISO]
- trans-Golgi network [ISO]
- transport vesicle [ISO]
- vesicle [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling.
Recent studies in humans and in genetic mouse models have identified Slit- and NTRK-like family (Slitrks) as candidate genes for neuropsychiatric disorders. All Slitrk isotypes are highly expressed in the CNS, where they mediate neurite outgrowth, synaptogenesis, and neuronal survival. However, the molecular mechanisms underlying these functions are not known. Here, we report that Slitrk5 modulates brain-derived neurotrophic factor (BDNF)-dependent ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID