SHC1
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin cytoskeleton organization [ISO]
- actin cytoskeleton reorganization [IMP]
- activation of MAPK activity [IMP, ISO]
- aging [ISO]
- angiogenesis [IMP]
- epidermal growth factor receptor signaling pathway [IBA, IDA]
- heart development [IMP]
- insulin receptor signaling pathway [IBA, ISO]
- neuron differentiation [ISO]
- neuron projection development [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of vasoconstriction [ISO]
- regulation of cell proliferation [IMP]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [ISO]
- receptor tyrosine kinase binding [IPI, ISO]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [ISO]
- receptor tyrosine kinase binding [IPI, ISO]
Gene Ontology Cellular Component
AXL
Gene Ontology Biological Process
- apoptotic cell clearance [IGI, IMP]
- blood vessel remodeling [IMP]
- cell differentiation [ISO]
- cellular response to extracellular stimulus [IDA]
- cellular response to hydrogen peroxide [ISO]
- cellular response to interferon-alpha [ISO]
- cellular response to lipopolysaccharide [ISO]
- enzyme linked receptor protein signaling pathway [IGI]
- erythrocyte homeostasis [IGI, IMP]
- forebrain cell migration [IGI]
- inflammatory response [IMP]
- natural killer cell differentiation [IGI]
- negative regulation of apoptotic process [IGI, IMP, ISO]
- negative regulation of dendritic cell apoptotic process [ISO]
- negative regulation of interferon-gamma production [ISO]
- negative regulation of lymphocyte activation [IGI]
- negative regulation of neuron apoptotic process [IGI, IMP]
- negative regulation of tumor necrosis factor production [IGI]
- neuron migration [IGI, IMP]
- ovulation cycle [IGI]
- phagocytosis [IGI, ISO]
- platelet activation [IMP]
- positive regulation of cytokine-mediated signaling pathway [ISO]
- positive regulation of natural killer cell differentiation [ISO]
- positive regulation of protein kinase B signaling [IMP, ISO]
- protein kinase B signaling [IGI, IMP]
- secretion by cell [IMP]
- spermatogenesis [IGI]
- substrate adhesion-dependent cell spreading [IMP]
- vagina development [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.
The Shc adaptor protein, hereafter referred to as ShcA, possesses two distinct phosphotyrosine-recognition modules, a C-terminal Src homology 2 (SH2) domain and an N-terminal phosphotyrosine-binding (PTB) domain, and is itself phosphorylated on tyrosine in response to many extracellular signals. Phosphorylation of human ShcA at Tyr-317 within its central (CH1) region induces binding to the Grb2 SH2 domain and is thereby ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID