BAIT
SENP1
SuPr-2
SUMO1/sentrin specific peptidase 1
GO Process (7)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic signaling pathway [IMP]
- cellular protein metabolic process [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- post-translational protein modification [TAS]
- protein desumoylation [IMP]
- protein sumoylation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PIAS3
ZMIZ5
protein inhibitor of activated STAT, 3
GO Process (2)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression.
The small ubiquitin-like modifier (SUMO) post-translationally modifies lysine residues of transcription factors and co-regulators and thereby contributes to an important layer of control of the activities of these transcriptional regulators. Likewise, deSUMOylation of these factors by the sentrin-specific proteases (SENPs) also plays a role in gene regulation, but whether SENPs functionally interact with other regulatory factors that control gene expression ... [more]
J. Biol. Chem. Oct. 05, 2018; 293(40);15439-15454 [Pubmed: 30082317]
Throughput
- Low Throughput
Curated By
- BioGRID