BAIT

CA2

CA-II, CAC, CAII, Car2, HEL-76
carbonic anhydrase II
Homo sapiens
PREY

SLC4A8

NBC3, NDCBE
solute carrier family 4, sodium bicarbonate cotransporter, member 8
GO Process (3)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA.

Loiselle FB, Morgan PE, Alvarez BV, Casey JR

Human NBC3 is an electroneutral Na(+)/HCO(3)(-) cotransporter expressed in heart, skeletal muscle, and kidney in which it plays an important role in HCO(3)(-) metabolism. Cytosolic enzyme carbonic anhydrase II (CAII) catalyzes the reaction CO(2) + H(2)O left arrow over right arrow HCO(3)(-) + H(+) in many tissues. We investigated whether NBC3, like some Cl(-)/HCO(3)(-) exchange proteins, could bind CAII and ... [more]

Am. J. Physiol., Cell Physiol. Jun. 01, 2004; 286(6);C1423-33 [Pubmed: 14736710]

Throughput

  • Low Throughput

Curated By

  • BioGRID